Crandore Hub

phase1PRMD

Personalized Repeated Measurement Design for Phase I Clinical Trials

Implements Bayesian phase I repeated measurement design that accounts for multidimensional toxicity endpoints and longitudinal efficacy measure from multiple treatment cycles. The package provides flags to fit a variety of model-based phase I design, including 1 stage models with or without individualized dose modification, 3-stage models with or without individualized dose modification, etc. Functions are provided to recommend dosage selection based on the data collected in the available patient cohorts and to simulate trial characteristics given design parameters. Yin, Jun, et al. (2017) <doi:10.1002/sim.7134>.

Versions across snapshots

VersionRepositoryFileSize
1.0.2 rolling linux/jammy R-4.5 phase1PRMD_1.0.2.tar.gz 182.3 KiB
1.0.2 rolling linux/noble R-4.5 phase1PRMD_1.0.2.tar.gz 182.3 KiB
1.0.2 rolling source/ R- phase1PRMD_1.0.2.tar.gz 64.5 KiB
1.0.2 latest linux/jammy R-4.5 phase1PRMD_1.0.2.tar.gz 182.3 KiB
1.0.2 latest linux/noble R-4.5 phase1PRMD_1.0.2.tar.gz 182.3 KiB
1.0.2 latest source/ R- phase1PRMD_1.0.2.tar.gz 64.5 KiB
1.0.2 2026-04-26 source/ R- phase1PRMD_1.0.2.tar.gz 64.5 KiB
1.0.2 2026-04-23 source/ R- phase1PRMD_1.0.2.tar.gz 64.5 KiB
1.0.2 2026-04-09 windows/windows R-4.5 phase1PRMD_1.0.2.zip 185.7 KiB
1.0.2 2025-04-20 source/ R- phase1PRMD_1.0.2.tar.gz 64.5 KiB

Dependencies (latest)

Depends

Imports