bbssr
Blinded Sample Size Re-Estimation for Binary Endpoints
Provides comprehensive tools for blinded sample size re-estimation (BSSR) in two-arm clinical trials with binary endpoints. Unlike traditional fixed-sample designs, BSSR allows adaptive sample size adjustments during trials while maintaining statistical integrity and study blinding. Implements five exact statistical tests: Pearson chi-squared, Fisher exact, Fisher mid-p, Z-pooled exact unconditional, and Boschloo exact unconditional tests. Supports restricted, unrestricted, and weighted BSSR approaches with exact Type I error control. Statistical methods based on Mehrotra et al. (2003) <doi:10.1111/1541-0420.00051> and Kieser (2020) <doi:10.1007/978-3-030-49528-2_21>.
Versions across snapshots
| Version | Repository | File | Size |
|---|---|---|---|
1.0.2 |
rolling linux/jammy R-4.5 | bbssr_1.0.2.tar.gz |
773.7 KiB |
1.0.2 |
rolling linux/noble R-4.5 | bbssr_1.0.2.tar.gz |
773.6 KiB |
1.0.2 |
rolling source/ R- | bbssr_1.0.2.tar.gz |
768.3 KiB |
1.0.2 |
latest linux/jammy R-4.5 | bbssr_1.0.2.tar.gz |
773.7 KiB |
1.0.2 |
latest linux/noble R-4.5 | bbssr_1.0.2.tar.gz |
773.6 KiB |
1.0.2 |
latest source/ R- | bbssr_1.0.2.tar.gz |
768.3 KiB |
1.0.2 |
2026-04-26 source/ R- | bbssr_1.0.2.tar.gz |
768.3 KiB |
1.0.2 |
2026-04-23 source/ R- | bbssr_1.0.2.tar.gz |
768.3 KiB |
1.0.2 |
2026-04-09 windows/windows R-4.5 | bbssr_1.0.2.zip |
781.7 KiB |