SynergyLMM
Statistical Framework for in Vivo Drug Combination Studies
A framework for evaluating drug combination effects in preclinical in vivo studies. 'SynergyLMM' provides functions to analyze longitudinal tumor growth experiments using mixed-effects models, perform time-resolved analyses of synergy and antagonism, evaluate model diagnostics and performance, and assess both post-hoc and a priori statistical power. The calculation of drug combination synergy follows the statistical framework provided by Demidenko and Miller (2019, <doi:10.1371/journal.pone.0224137>). The implementation and analysis of linear mixed-effect models is based on the methods described by Pinheiro and Bates (2000, <doi:10.1007/b98882>), and Gałecki and Burzykowski (2013, <doi:10.1007/978-1-4614-3900-4>).
Versions across snapshots
| Version | Repository | File | Size |
|---|---|---|---|
1.1.2 |
rolling linux/jammy R-4.5 | SynergyLMM_1.1.2.tar.gz |
3.7 MiB |
1.1.2 |
rolling linux/noble R-4.5 | SynergyLMM_1.1.2.tar.gz |
3.7 MiB |
1.1.2 |
rolling source/ R- | SynergyLMM_1.1.2.tar.gz |
4.2 MiB |
1.1.2 |
latest linux/jammy R-4.5 | SynergyLMM_1.1.2.tar.gz |
3.7 MiB |
1.1.2 |
latest linux/noble R-4.5 | SynergyLMM_1.1.2.tar.gz |
3.7 MiB |
1.1.2 |
latest source/ R- | SynergyLMM_1.1.2.tar.gz |
4.2 MiB |
1.1.2 |
2026-04-26 source/ R- | SynergyLMM_1.1.2.tar.gz |
4.2 MiB |
1.1.2 |
2026-04-23 source/ R- | SynergyLMM_1.1.2.tar.gz |
4.2 MiB |
1.1.2 |
2026-04-09 windows/windows R-4.5 | SynergyLMM_1.1.2.zip |
3.8 MiB |
1.0.1 |
2025-04-20 source/ R- | SynergyLMM_1.0.1.tar.gz |
3.5 MiB |