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RTSA

'Trial Sequential Analysis' for Error Control and Inference in Sequential Meta-Analyses

Frequentist sequential meta-analysis based on 'Trial Sequential Analysis' (TSA) in programmed in Java by the Copenhagen Trial Unit (CTU). The primary function is the calculation of group sequential designs for meta-analysis to be used for planning and analysis of both prospective and retrospective sequential meta-analyses to preserve type-I-error control under sequential testing. 'RTSA' includes tools for sample size and trial size calculation for meta-analysis and core meta-analyses methods such as fixed-effect and random-effects models and forest plots. TSA is described in Wetterslev et. al (2008) <doi:10.1016/j.jclinepi.2007.03.013>. The methods for deriving the group sequential designs are based on Jennison and Turnbull (1999, ISBN:9780849303166).

Versions across snapshots

VersionRepositoryFileSize
0.2.2 rolling linux/jammy R-4.5 RTSA_0.2.2.tar.gz 1.5 MiB
0.2.2 rolling linux/noble R-4.5 RTSA_0.2.2.tar.gz 1.5 MiB
0.2.2 rolling source/ R- RTSA_0.2.2.tar.gz 1.2 MiB
0.2.2 latest linux/jammy R-4.5 RTSA_0.2.2.tar.gz 1.5 MiB
0.2.2 latest linux/noble R-4.5 RTSA_0.2.2.tar.gz 1.5 MiB
0.2.2 latest source/ R- RTSA_0.2.2.tar.gz 1.2 MiB
0.2.2 2026-04-26 source/ R- RTSA_0.2.2.tar.gz 1.2 MiB
0.2.2 2026-04-23 source/ R- RTSA_0.2.2.tar.gz 1.2 MiB
0.2.2 2026-04-09 windows/windows R-4.5 RTSA_0.2.2.zip 1.8 MiB
0.2.2 2025-04-20 source/ R- RTSA_0.2.2.tar.gz 1.2 MiB

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