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LTFHPlus

Implementation of LT-FH++

Implementation of LT-FH++, an extension of the liability threshold family history (LT-FH) model. LT-FH++ uses a Gibbs sampler for sampling from the truncated multivariate normal distribution and allows for flexible family structures. LT-FH++ was first described in Pedersen, Emil M., et al. (2022) <doi:10.1016/j.ajhg.2022.01.009> as an extension to LT-FH with more flexible family structures, and again as the age-dependent liability threshold (ADuLT) model Pedersen, Emil M., et al. (2023) <https://www.nature.com/articles/s41467-023-41210-z> as an alternative to traditional time-to-event genome-wide association studies, where family history was not considered.

Versions across snapshots

VersionRepositoryFileSize
2.2.0 rolling linux/jammy R-4.5 LTFHPlus_2.2.0.tar.gz 345.4 KiB
2.2.0 rolling linux/noble R-4.5 LTFHPlus_2.2.0.tar.gz 347.2 KiB
2.2.0 rolling source/ R- LTFHPlus_2.2.0.tar.gz 84.7 KiB
2.2.0 latest linux/jammy R-4.5 LTFHPlus_2.2.0.tar.gz 345.4 KiB
2.2.0 latest linux/noble R-4.5 LTFHPlus_2.2.0.tar.gz 347.2 KiB
2.2.0 latest source/ R- LTFHPlus_2.2.0.tar.gz 84.7 KiB
2.2.0 2026-04-26 source/ R- LTFHPlus_2.2.0.tar.gz 84.7 KiB
2.2.0 2026-04-23 source/ R- LTFHPlus_2.2.0.tar.gz 84.7 KiB
2.2.0 2026-04-09 windows/windows R-4.5 LTFHPlus_2.2.0.zip 667.3 KiB
2.1.2 2025-04-20 source/ R- LTFHPlus_2.1.2.tar.gz 77.4 KiB

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