HetSeq
Identifying Modulators of Cellular Responses Leveraging Intercellular Heterogeneity
Cellular responses to perturbations are highly heterogeneous and depend largely on the initial state of cells. Connecting post-perturbation cells via cellular trajectories to untreated cells (e.g. by leveraging metabolic labeling information) enables exploitation of intercellular heterogeneity as a combined knock-down and overexpression screen to identify pathway modulators, termed Heterogeneity-seq (see 'Berg et al' <doi:10.1101/2024.10.28.620481>). This package contains functions to generate cellular trajectories based on scSLAM-seq (single-cell, thiol-(SH)-linked alkylation of RNA for metabolic labelling sequencing) time courses, functions to identify pathway modulators and to visualize the results.
Versions across snapshots
| Version | Repository | File | Size |
|---|---|---|---|
0.1.0 |
rolling source/ R- | HetSeq_0.1.0.tar.gz |
14.2 KiB |
0.1.0 |
rolling linux/jammy R-4.5 | HetSeq_0.1.0.tar.gz |
72.6 KiB |
0.1.0 |
rolling linux/noble R-4.5 | HetSeq_0.1.0.tar.gz |
72.6 KiB |
0.1.0 |
latest source/ R- | HetSeq_0.1.0.tar.gz |
14.2 KiB |
0.1.0 |
latest linux/jammy R-4.5 | HetSeq_0.1.0.tar.gz |
72.6 KiB |
0.1.0 |
latest linux/noble R-4.5 | HetSeq_0.1.0.tar.gz |
72.6 KiB |
0.1.0 |
2026-04-23 source/ R- | HetSeq_0.1.0.tar.gz |
14.2 KiB |
0.1.0 |
2026-04-09 windows/windows R-4.5 | HetSeq_0.1.0.zip |
75.2 KiB |
0.1.0 |
2025-04-20 source/ R- | HetSeq_0.1.0.tar.gz |
14.2 KiB |