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HDXBoxeR

Analysis of Hydrogen-Deuterium Exchange Mass-Spectrometry Data

A protocol that facilitates the processing and analysis of Hydrogen-Deuterium Exchange Mass Spectrometry data using p-value statistics and Critical Interval analysis. It provides a pipeline for analyzing data from 'HDXExaminer' (Sierra Analytics, Trajan Scientific), automating matching and comparison of protein states through Welch's T-test and the Critical Interval statistical framework. Additionally, it simplifies data export, generates 'PyMol' scripts, and ensures calculations meet publication standards. 'HDXBoxeR' assists in various aspects of hydrogen-deuterium exchange data analysis, including reprocessing data, calculating parameters, identifying significant peptides, generating plots, and facilitating comparison between protein states. For details check papers by Hageman and Weis (2019) <doi:10.1021/acs.analchem.9b01325> and Masson et al. (2019) <doi:10.1038/s41592-019-0459-y>. 'HDXBoxeR' citation: Janowska et al. (2024) <doi:10.1093/bioinformatics/btae479>.

Versions across snapshots

VersionRepositoryFileSize
0.0.2 rolling source/ R- HDXBoxeR_0.0.2.tar.gz 998.2 KiB
0.0.2 rolling linux/jammy R-4.5 HDXBoxeR_0.0.2.tar.gz 1.2 MiB
0.0.2 rolling linux/noble R-4.5 HDXBoxeR_0.0.2.tar.gz 1.2 MiB
0.0.2 latest source/ R- HDXBoxeR_0.0.2.tar.gz 998.2 KiB
0.0.2 latest linux/jammy R-4.5 HDXBoxeR_0.0.2.tar.gz 1.2 MiB
0.0.2 latest linux/noble R-4.5 HDXBoxeR_0.0.2.tar.gz 1.2 MiB
0.0.2 2026-04-23 source/ R- HDXBoxeR_0.0.2.tar.gz 998.2 KiB
0.0.2 2026-04-09 windows/windows R-4.5 HDXBoxeR_0.0.2.zip 1.2 MiB
0.0.2 2025-04-20 source/ R- HDXBoxeR_0.0.2.tar.gz 998.2 KiB

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