GRAB

Genome-Wide Robust Analysis for Biobank Data (GRAB)

Provides a comprehensive suite of genome-wide association study (GWAS) methods specifically designed for biobank-scale data, including but not limited to, robust approaches for time-to-event traits (Li et al., 2025 <doi:10.1038/s43588-025-00864-z>) and ordinal categorical traits (Bi et al., 2021 <doi:10.1016/j.ajhg.2021.03.019>). The package also offers general frameworks for GWAS of any trait type (Bi et al., 2020 <doi:10.1016/j.ajhg.2020.06.003>), while accounting for sample relatedness (Xu et al., 2025 <doi:10.1038/s41467-025-56669-1>) or population structure (Ma et al., 2025 <doi:10.1186/s13059-025-03827-9>). By accurately approximating score statistic distributions using saddlepoint approximation (SPA), these methods can effectively control type I error rates for rare variants and in the presence of unbalanced phenotype distributions. Additionally, the package includes functions for simulating genotype and phenotype data to support research and method development.

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