wnl
Minimization Tool for Pharmacokinetic-Pharmacodynamic Data Analysis
This is a set of minimization tools (maximum likelihood estimation and least square fitting) to solve examples in the Johan Gabrielsson and Dan Weiner's book "Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications" 5th ed. (ISBN:9198299107). Examples include linear and nonlinear compartmental model, turn-over model, single or multiple dosing bolus/infusion/oral models, allometry, toxicokinetics, reversible metabolism, in-vitro/in-vivo extrapolation, enterohepatic circulation, metabolite modeling, Emax model, inhibitory model, tolerance model, oscillating response model, enantiomer interaction model, effect compartment model, drug-drug interaction model, receptor occupancy model, and rebound phenomena model.
Versions across snapshots
| Version | Repository | File | Size |
|---|---|---|---|
0.8.5 |
rolling linux/jammy R-4.5 | wnl_0.8.5.tar.gz |
200.5 KiB |
0.8.5 |
rolling linux/noble R-4.5 | wnl_0.8.5.tar.gz |
200.3 KiB |
0.8.5 |
rolling source/ R- | wnl_0.8.5.tar.gz |
107.5 KiB |
0.8.5 |
latest linux/jammy R-4.5 | wnl_0.8.5.tar.gz |
200.5 KiB |
0.8.5 |
latest linux/noble R-4.5 | wnl_0.8.5.tar.gz |
200.3 KiB |
0.8.5 |
latest source/ R- | wnl_0.8.5.tar.gz |
107.5 KiB |
0.8.5 |
2026-04-26 source/ R- | wnl_0.8.5.tar.gz |
107.5 KiB |
0.8.5 |
2026-04-23 source/ R- | wnl_0.8.5.tar.gz |
107.5 KiB |
0.8.5 |
2026-04-09 windows/windows R-4.5 | wnl_0.8.5.zip |
203.3 KiB |
0.8.3 |
2025-04-20 source/ R- | wnl_0.8.3.tar.gz |
98.8 KiB |