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Optimal Sample Size and Progression Criteria for Three-Outcome Trials

Find the optimal decision rules (AKA progression criteria) and sample size for clinical trials with three (stop/pause/go) outcomes. Both binary and continuous endpoints can be accommodated, as can cases where an adjustment is planned following a pause outcome. For more details see Wilson et al. (2024) <doi:10.1186/s12874-024-02351-x>.

Versions across snapshots

VersionRepositoryFileSize
1.0.3 rolling linux/jammy R-4.5 tout_1.0.3.tar.gz 100.5 KiB
1.0.3 rolling linux/noble R-4.5 tout_1.0.3.tar.gz 100.4 KiB
1.0.3 rolling source/ R- tout_1.0.3.tar.gz 90.6 KiB
1.0.3 latest linux/jammy R-4.5 tout_1.0.3.tar.gz 100.5 KiB
1.0.3 latest linux/noble R-4.5 tout_1.0.3.tar.gz 100.4 KiB
1.0.3 latest source/ R- tout_1.0.3.tar.gz 90.6 KiB
1.0.3 2026-04-26 source/ R- tout_1.0.3.tar.gz 90.6 KiB
1.0.3 2026-04-23 source/ R- tout_1.0.3.tar.gz 90.6 KiB
1.0.3 2026-04-09 windows/windows R-4.5 tout_1.0.3.zip 103.7 KiB

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