pssmooth
Flexible and Efficient Evaluation of Principal Surrogates/Treatment Effect Modifiers
Implements estimation and testing procedures for evaluating an intermediate biomarker response as a principal surrogate of a clinical response to treatment (i.e., principal stratification effect modification analysis), as described in Juraska M, Huang Y, and Gilbert PB (2020), Inference on treatment effect modification by biomarker response in a three-phase sampling design, Biostatistics, 21(3): 545-560 <doi:10.1093/biostatistics/kxy074>. The methods avoid the restrictive 'placebo structural risk' modeling assumption common to past methods and further improve robustness by the use of nonparametric kernel smoothing for biomarker density estimation. A randomized controlled two-group clinical efficacy trial is assumed with an ordered categorical or continuous univariate biomarker response measured at a fixed timepoint post-randomization and with a univariate baseline surrogate measure allowed to be observed in only a subset of trial participants with an observed biomarker response (see the flexible three-phase sampling design in the paper for details). Bootstrap-based procedures are available for pointwise and simultaneous confidence intervals and testing of four relevant hypotheses. Summary and plotting functions are provided for estimation results.
Versions across snapshots
| Version | Repository | File | Size |
|---|---|---|---|
1.0.3 |
rolling linux/jammy R-4.5 | pssmooth_1.0.3.tar.gz |
106.5 KiB |
1.0.3 |
rolling linux/noble R-4.5 | pssmooth_1.0.3.tar.gz |
106.5 KiB |
1.0.3 |
rolling source/ R- | pssmooth_1.0.3.tar.gz |
18.7 KiB |
1.0.3 |
latest linux/jammy R-4.5 | pssmooth_1.0.3.tar.gz |
106.5 KiB |
1.0.3 |
latest linux/noble R-4.5 | pssmooth_1.0.3.tar.gz |
106.5 KiB |
1.0.3 |
latest source/ R- | pssmooth_1.0.3.tar.gz |
18.7 KiB |
1.0.3 |
2026-04-26 source/ R- | pssmooth_1.0.3.tar.gz |
18.7 KiB |
1.0.3 |
2026-04-23 source/ R- | pssmooth_1.0.3.tar.gz |
18.7 KiB |
1.0.3 |
2026-04-09 windows/windows R-4.5 | pssmooth_1.0.3.zip |
109.2 KiB |
1.0.3 |
2025-04-20 source/ R- | pssmooth_1.0.3.tar.gz |
18.7 KiB |