dtpcrm
Dose Transition Pathways for Continual Reassessment Method
Provides the dose transition pathways (DTP) to project in advance the doses recommended by a model-based design for subsequent patients (stay, escalate, deescalate or stop early) using all the accumulated toxicity information; See Yap et al (2017) <doi: 10.1158/1078-0432.CCR-17-0582>. DTP can be used as a design and an operational tool and can be displayed as a table or flow diagram. The 'dtpcrm' package also provides the modified continual reassessment method (CRM) and time-to-event CRM (TITE-CRM) with added practical considerations to allow stopping early when there is sufficient evidence that the lowest dose is too toxic and/or there is a sufficient number of patients dosed at the maximum tolerated dose.
Versions across snapshots
| Version | Repository | File | Size |
|---|---|---|---|
0.1.1 |
rolling source/ R- | dtpcrm_0.1.1.tar.gz |
127.9 KiB |
0.1.1 |
latest source/ R- | dtpcrm_0.1.1.tar.gz |
127.9 KiB |
0.1.1 |
2026-04-09 windows/windows R-4.5 | dtpcrm_0.1.1.zip |
187.5 KiB |