Crandore Hub

TaxaNorm

Feature-Wise Normalization for Microbiome Sequencing Data

A novel feature-wise normalization method based on a zero-inflated negative binomial model. This method assumes that the effects of sequencing depth vary for each taxon on their mean and also incorporates a rational link of zero probability and taxon dispersion as a function of sequencing depth. Ziyue Wang, Dillon Lloyd, Shanshan Zhao, Alison Motsinger-Reif (2023) <doi:10.1101/2023.10.31.563648>.

README

# TaxaNorm <img src="man/figures/logo-hex.png" width="150" align="right" />
TaxNorm is the R package for a novel feature-wise normalization method for microbiome data based on zero-inflated negative binomial model. This method assumes that the effects of sequencing depth vary for each taxon on their mean and incorporates a rational link of zero probability and taxon dispersion as a function of sequencing depth to better capture the microbiome data nature.

## Installation


Current stable release:

```r
install.packages("TaxaNorm")
```

Build from GitHub:

```r
if (!require(remotes)) install.packages("remotes")
remotes::install_github("wangziyue57/TaxaNorm", 
                        dependencies = TRUE, 
                        build_vignettes = TRUE)
```



## Citation

Versions across snapshots

VersionRepositoryFileSize
2.4 rolling linux/jammy R-4.5 TaxaNorm_2.4.tar.gz 582.7 KiB
2.4 rolling linux/noble R-4.5 TaxaNorm_2.4.tar.gz 582.7 KiB
2.4 rolling source/ R- TaxaNorm_2.4.tar.gz 582.7 KiB
2.4 latest linux/jammy R-4.5 TaxaNorm_2.4.tar.gz 582.7 KiB
2.4 latest linux/noble R-4.5 TaxaNorm_2.4.tar.gz 582.7 KiB
2.4 latest source/ R- TaxaNorm_2.4.tar.gz 582.7 KiB
2.4 2026-04-26 source/ R- TaxaNorm_2.4.tar.gz 582.7 KiB
2.4 2026-04-23 source/ R- TaxaNorm_2.4.tar.gz 582.7 KiB
2.4 2025-04-20 source/ R- TaxaNorm_2.4.tar.gz 582.7 KiB

Dependencies (latest)

Depends

Imports

Suggests