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MixTwice

Large-Scale Hypothesis Testing by Variance Mixing

Implements large-scale hypothesis testing by variance mixing. It takes two statistics per testing unit -- an estimated effect and its associated squared standard error -- and fits a nonparametric, shape-constrained mixture separately on two latent parameters. It reports local false discovery rates (lfdr) and local false sign rates (lfsr). Manuscript describing algorithm of MixTwice: Zheng et al(2021) <doi: 10.1093/bioinformatics/btab162>.

Versions across snapshots

VersionRepositoryFileSize
2.0 rolling linux/jammy R-4.5 MixTwice_2.0.tar.gz 2.0 MiB
2.0 rolling linux/noble R-4.5 MixTwice_2.0.tar.gz 2.0 MiB
2.0 rolling source/ R- MixTwice_2.0.tar.gz 2.0 MiB
2.0 latest linux/jammy R-4.5 MixTwice_2.0.tar.gz 2.0 MiB
2.0 latest linux/noble R-4.5 MixTwice_2.0.tar.gz 2.0 MiB
2.0 latest source/ R- MixTwice_2.0.tar.gz 2.0 MiB
2.0 2026-04-26 source/ R- MixTwice_2.0.tar.gz 2.0 MiB
2.0 2026-04-23 source/ R- MixTwice_2.0.tar.gz 2.0 MiB
2.0 2026-04-09 windows/windows R-4.5 MixTwice_2.0.zip 2.0 MiB
2.0 2025-04-20 source/ R- MixTwice_2.0.tar.gz 2.0 MiB

Dependencies (latest)

Imports