HybridDesign
Hybrid Design for Phase I Dose-Finding Studies
The Hybrid design is a combination of model-assisted design (e.g., the modified Toxicity Probability Interval design) with dose-toxicity model-based design for phase I dose-finding studies. The hybrid design controls the overdosing toxicity well and leads to a recommended dose closer to the true maximum tolerated dose (MTD) due to its ability to calibrate for an intermediate dose. More details can be found in Liao et al. 2022 <doi:10.1002/ijc.34203>.
Versions across snapshots
| Version | Repository | File | Size |
|---|---|---|---|
1.0 |
rolling source/ R- | HybridDesign_1.0.tar.gz |
7.5 KiB |
1.0 |
rolling linux/jammy R-4.5 | HybridDesign_1.0.tar.gz |
40.5 KiB |
1.0 |
rolling linux/noble R-4.5 | HybridDesign_1.0.tar.gz |
40.6 KiB |
1.0 |
latest source/ R- | HybridDesign_1.0.tar.gz |
7.5 KiB |
1.0 |
latest linux/jammy R-4.5 | HybridDesign_1.0.tar.gz |
40.5 KiB |
1.0 |
latest linux/noble R-4.5 | HybridDesign_1.0.tar.gz |
40.6 KiB |
1.0 |
2026-04-26 source/ R- | HybridDesign_1.0.tar.gz |
7.5 KiB |
1.0 |
2026-04-23 source/ R- | HybridDesign_1.0.tar.gz |
7.5 KiB |
1.0 |
2026-04-09 windows/windows R-4.5 | HybridDesign_1.0.zip |
43.5 KiB |
1.0 |
2025-04-20 source/ R- | HybridDesign_1.0.tar.gz |
7.5 KiB |