DTEBOP2
Bayesian Optimal Phase II Randomized Clinical Trial Design with Delayed Outcomes
Implements a Bayesian Optimal Phase II design (DTE-BOP2) for trials with delayed treatment effects, particularly relevant to immunotherapy studies where treatment benefits may emerge after a delay. The method builds upon the BOP2 framework and incorporates uncertainty in the delay timepoint through a truncated gamma prior, informed by expert knowledge or default settings. Supports two-arm trial designs with functionality for sample size determination, interim and final analyses, and comprehensive simulation under various delay and design scenarios. Ensures rigorous type I and II error control while improving trial efficiency and power when the delay effect is present. A manuscript describing the methodology is under development and will be formally referenced upon publication.
Versions across snapshots
| Version | Repository | File | Size |
|---|---|---|---|
1.0.3 |
rolling source/ R- | DTEBOP2_1.0.3.tar.gz |
218.2 KiB |
1.0.3 |
latest source/ R- | DTEBOP2_1.0.3.tar.gz |
218.2 KiB |
1.0.3 |
2026-04-09 windows/windows R-4.5 | DTEBOP2_1.0.3.zip |
267.4 KiB |