DANDELION
Discovery of Candidate Disease Genes Using Trans-Regulatory Effects
Implements the DANDELION method for prioritizing candidate disease-related proximal genes by integrating trans-regulatory association p-values and gene-level trait association p-values. The statistical testing framework builds on the divide-aggregate composite-null test described by Liu et al. (2022) <doi:10.1080/01621459.2021.1914634>. The biological application and SNP/gene-based prioritization workflow are motivated by Salamone et al. (under review), "Leveraging trans-gene regulation prioritizes central genes and pathways in asthma". The package provides functions for identifying distal-proximal gene pairs, organizing significant pairs into genomic loci, and visualizing resulting gene networks.
Versions across snapshots
| Version | Repository | File | Size |
|---|---|---|---|
0.1.0 |
rolling linux/jammy R-4.5 | DANDELION_0.1.0.tar.gz |
59.0 KiB |
0.1.0 |
rolling linux/noble R-4.5 | DANDELION_0.1.0.tar.gz |
58.8 KiB |
0.1.0 |
rolling source/ R- | DANDELION_0.1.0.tar.gz |
11.0 KiB |
0.1.0 |
latest linux/jammy R-4.5 | DANDELION_0.1.0.tar.gz |
59.0 KiB |
0.1.0 |
latest linux/noble R-4.5 | DANDELION_0.1.0.tar.gz |
58.8 KiB |
0.1.0 |
latest source/ R- | DANDELION_0.1.0.tar.gz |
11.0 KiB |
0.1.0 |
2026-04-23 source/ R- | DANDELION_0.1.0.tar.gz |
0 B |