BElikelihood
Likelihood Method for Evaluating Bioequivalence
A likelihood method is implemented to present evidence for evaluating bioequivalence (BE). The functions use bioequivalence data [area under the blood concentration-time curve (AUC) and peak concentration (Cmax)] from various crossover designs commonly used in BE studies including a fully replicated, a partially replicated design, and a conventional 2x2 crossover design. They will calculate the profile likelihoods for the mean difference, total standard deviation ratio, and within subject standard deviation ratio for a test and a reference drug. A plot of a standardized profile likelihood can be generated along with the maximum likelihood estimate and likelihood intervals, which present evidence for bioequivalence. See Liping Du and Leena Choi (2015) <doi:10.1002/pst.1661>.
Versions across snapshots
| Version | Repository | File | Size |
|---|---|---|---|
1.1 |
rolling linux/jammy R-4.5 | BElikelihood_1.1.tar.gz |
321.2 KiB |
1.1 |
rolling linux/noble R-4.5 | BElikelihood_1.1.tar.gz |
321.1 KiB |
1.1 |
rolling source/ R- | BElikelihood_1.1.tar.gz |
545.7 KiB |
1.1 |
latest linux/jammy R-4.5 | BElikelihood_1.1.tar.gz |
321.2 KiB |
1.1 |
latest linux/noble R-4.5 | BElikelihood_1.1.tar.gz |
321.1 KiB |
1.1 |
latest source/ R- | BElikelihood_1.1.tar.gz |
545.7 KiB |
1.1 |
2026-04-26 source/ R- | BElikelihood_1.1.tar.gz |
545.7 KiB |
1.1 |
2026-04-23 source/ R- | BElikelihood_1.1.tar.gz |
545.7 KiB |
1.1 |
2026-04-09 windows/windows R-4.5 | BElikelihood_1.1.zip |
324.9 KiB |
1.1 |
2025-04-20 source/ R- | BElikelihood_1.1.tar.gz |
545.7 KiB |