AHTauDesign
Truncation Time Selection for Average Hazard Analyses
Implements a two-stage, design-informed framework for selecting the truncation time in time-to-event trials analyzed with the average hazard estimand, motivated by pediatric oncology settings with small samples, slow accrual, and limited follow-up. Stage 1 validates a clinically proposed truncation time against the planned design using simulation-based diagnostics for risk-set support, follow-up coverage, estimability, and estimator stability, classifying it as Pass, Borderline, or Fail. Stage 2 performs constrained optimization over a grid of candidate truncation times within a clinical-distance window, maximizing a utility subject to feasibility constraints, with an independent evaluation run to assess the selected time. Supports proportional-hazards, early-, and delayed-effect patterns, uniform accrual with administrative censoring, and calibrated exponential random censoring.
Versions across snapshots
| Version | Repository | File | Size |
|---|---|---|---|
0.1.0 |
rolling linux/jammy R-4.5 | AHTauDesign_0.1.0.tar.gz |
131.9 KiB |
0.1.0 |
rolling linux/noble R-4.5 | AHTauDesign_0.1.0.tar.gz |
131.9 KiB |
0.1.0 |
rolling source/ R- | AHTauDesign_0.1.0.tar.gz |
69.9 KiB |
0.1.0 |
latest linux/jammy R-4.5 | AHTauDesign_0.1.0.tar.gz |
131.9 KiB |
0.1.0 |
latest linux/noble R-4.5 | AHTauDesign_0.1.0.tar.gz |
131.9 KiB |
0.1.0 |
latest source/ R- | AHTauDesign_0.1.0.tar.gz |
69.9 KiB |
0.1.0 |
2026-04-23 source/ R- | AHTauDesign_0.1.0.tar.gz |
0 B |